• Mackie TD, Kim BY, Subramanya AR, Bain DJ, O’Donnell AF, Welling PA, Brodsky JL. The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK). J Biol Chem. 2018 Mar 2;293(9):3201-3217. Epub 2018 Jan 8. PMID: 29311259.

  • Boyd-Shiwarski CR, Shiwarski DJ, Roy A, Nkashama LJ, Namboodiri HN, Xie J, McClain KL, Marciszyn A, Kleyman TR, Tan RJ, Stolz DB, Puthenveedu MA, Huang CL, Subramanya AR. Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent. Mol Biol Cell 2018 Feb 15;29(4):499-509. Epub 2017 Dec 13. PMID: 29237822.

  • Tomilin VN, Zaika O, Subramanya AR, Pochynyuk O. Dietary K+ and Cl- independently regulate basolateral conductance in principal and intercalated cells of the collecting duct. Pflugers Arch. 2018. Feb 15;29(4):499-509. PMID: 29237822.


  • Boyd-Shiwarski CR and Subramanya AR. The Renal Response to Potassium Stress: Integrating Past with Present. Curr Op Neph Hypertens 2017 Sep;26(5):411-418. PMID:28614118

  • O’Donnell BM, Mackie TD, Subramanya AR, Brodsky JL. Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome. J Biol Chem. 2017 Aug 4;292(31):12813-12827. Epub 2017 Jun 19. PMID: 28630040.

  • Al-Qusairi L, Basquin D, Roy A, Rajamram RD, Maillard M, Subramanya AR, Staub O. Renal tubular ubiquitin protein ligase NEDD4-2 is required for renal adaptation during long-term potassium depletion. J Am Soc Nephrol. 2017 Aug;28(8):2431-2442. Epub 2017 Mar 13. PMID: 2829184.


  • Bhuiyan MIH, Song S, Yuan H, Begum G, Kofler J, Kahle KT, Yang SS, Lin SH, Alper SL, Subramanya AR, Sun D. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. J Cereb Blood Flow Metab. 2017 Aug;28(8):2431-2442. Epub 2016 Jan 1. PMID: 27798271.

  • Labilloy A, Pereira EM, Roy A, Subramanya AR, Do Monte SJH, Weisz OA. Characterization and phosphoproteomic analysis of a human podocyte model of Fabry disease generated using the CRISPR/Cas9 genome editing system. Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F1015-F1024. Epub 2016 Sep 28. PMID: 27681560.

  • Al-Qusairi L, Basquin D, Roy A, Stifanelli M, Rajaran RD, Debonneville A, Nita I, Maillard MP, Loffing J, Subramanya AR, Staub O. Renal-tubular SGK1 deficiency causes impaired K+ excretion via that loss of regulation of Nedd4-2/WNK1 and ENaC. Am J Physiol Renal Physiol. Epub 2016 Mar 23. PMID: 27009335.

  • Webb TN, Carrisoza-Gaytan R, Montalbetti N, Rued AC, Roy A, Socovich AM, Subramanya AR, Satlin LM, Kleyman TR, Carattino MD. Cell specific regulation of WNK1 by dietary K+. Am J Physiol Renal Physiol. 2016 Jan 1;310(1):F15-26. Epub 14 Oct 2015. PMID: 26662201.


  • Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YPC, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR. Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest 2015. Epub 2015 Aug 4. PMID: 26241057
    Research highlight in Nature Reviews Nephrology: Epub 2015 Aug 25. PMID: 26303779

  • Roy A, Goodman JH, Begum G, Donnelly BF, Pittman G, Weinman EJ, Sun D, Subramanya AR. Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing. Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F366-76. Epub 2014 Dec 4. PMID 25477473.

  • Ellison DH, Subramanya AR. Clinical use of diuretics. In: Oxford Textbook of Clinical Nephrology. Fourth Edition (Vol I; p. 299-323). Editors: Turner N, Lameirer N, Goldsmith DJ, Winearls CG, Himmelfarb J, Remuzzi G. Oxford University Press. 2015

  • Subramanya AR. Thiazide-sensitive NaCl Cotransporter. In: Ion Channels and Transporters of Epithelia in Health and Disease. First Edition. Editors: Hamilton K, Devor DC, and Harvey B. Springer, New York. 2015.


  • Subramanya AR, Ellison DH. Distal Convoluted Tubule. Clin J Am Soc Nephrol. 2014 Dec 5;9(12):2147-63. Epub 2014 May 22. PMID: 24855283. 
    NephJC website commentary: http://www.nephjc/dct


  • Wang Z, Subramanya AR, Satlin LM, Pastor-Soler NM, Carattino MD, Kleyman TR. Regulation of large conductance Ca2+-activated K+ channels by WNK4 kinase. Am J Physiol Cell Physiol. Epub 2013 Jul 24. PMID: 23885063.

  • Buck TM, Plavchak L, Roy A, Donnelly BF, Kashlan OB, Kleyman TR, Subramanya AR, Brodsky JL. The Lhs1/GRP170 cochaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel. J Biol Chem. 2013 Jun 21;288(25):18366-80. Epub 2013 May 13. PMID: 23645669.

  • Donnelly BF, Needham PG, Snyder AC, Roy A, Khadem S, Brodsky JL, Subramanya AR. Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter ER-associated degradation and biogenesis. J Biol Chem. 2013 May 3;288(18):13124-35. Epub 2013 Mar 12.

2012 and prior

  • Subramanya AR, Ellison DH. Diuretic Therapy. In: Core Concepts in Disorders of Fluid, Electrolytes, and Acid-Base Balance. 2012 Edition (p.171-203). Editors: Sayegh M and Mount D. Springer, New York. 2012.

  • Subramanya AR, Pastor-Soler NM, Reeves B, Hallows KR. Tubular Sodium Transport. In: Diseases of the Kidney, 9th Edition (Vol I; p.159-193). Editors: Schrier RW, Nielson E, Molitoris B, Coffman T, and Falk R. Lippincott Williams & Wilkins, Philadelphia, Pennsylvania. 2012.

  • Needham PG, Mikoluk K, Khadem S, Snyder AC, Subramanya AR, Brodsky JL. The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent ER associated degradation. J Biol Chem. 2011 Dec 23;286(51):43611-21. Epub 2011 Oct 25. PMID: 22027832.

  • Subramanya AR, Welling PA. Toward an understanding of hypertension resistance. Am J Physiol Renal Physiol. 2011 Apr;300(4):F838-9. Epub 2011 Feb 16. PMID: 2135498.

  • Subramanya AR, Ellison DH. Sorting out the lysosomal trafficking of the thiazide-sensitive NaCl cotransporter. J Am Soc Nephrol. 2010 Jan;21(1):7-9. Epub 2009 Dec 3. PMID: 19959708.

  • Rozansky DJ, Cornwall T, Subramanya AR, Yang YF, David L, Zhu X, Yang CL, Ellison DH. Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. J Clin Invest. 2009 Sep;119(9)2601-12. Epub2009 Aug 17. PMID:19690383.

  • Subramanya AR**, Liu J, Ellison DH, Wade JB, Welling PA. WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction. J Biol Chem. 2009 Jul 3;284(27):18471-80. Epub 2009 Apr 28. PMID: 19401467.

  • Wang Y, McArdle PF, Wade JB, O’Connell J, Dorff SE, Shah S, Shi X, Pan L, Rampersaud E, Shen H, Kim JD, Subramanya AR, Steinle NI, Ober CC, Welling PA, Chakravarti A, Weder AB, Cooper RR, Mitchell BD, Shuldiner AR, Chang YPC. Whole genome association study identifies STK39 as a novel hypertension susceptibility gene. Proc Natl Acad Sci USA. 2009 Jan 6;106(1):226-31. Epub 2008 Dec 29. PMID: 19114657.

  • Wade JB, Fang L, Liu J, Li D, Yang CL, Subramanya AR, Maouyo D, Mason A, Ellison DH, Welling PA. WNK1 kinase isoform switch regulates renal potassium excretion. Proc Natl Acad Sci U S A 2006 May 30;103(22):8558-63. Epub 2006 May 18. PMID: 16709664

  • Fu Y, Subramanya A, Rozansky DJ, Cohen DM. WNK kinases influence TRPV4 function and localization. Am J Physiol Renal Physiol 2006 Jun;290(6):F1305-14. Epub 2006 Jan 10. PMID: 16403833.

  • Subramanya AR, Yang CL, McCormick JA, Ellison DH. WNK kinases regulate sodium chloride and potassium handling by the aldosterone-sensitive distal nephron. Kidney In. 2006 Aug;70(4)630-4. Epub2006 Jul 5. Review. PMID: 16820787

  • Subramanya AR, Yang CL, Zhu XM, Ellison DH. Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. Am J Physiol Renal Physiol. 2006 Mar;290(3):F619-24. Epub 2005 Oct 4. PMID: 16204408.

  • Subramanya A, Houghton DL, Watnick S. Steroid-responsive idiopathic glomerular capillary endotheliosis: case report and literature review. Am J Kidney Dis 2005 Jun; 45(6):1090-5. PMID: 15957139.

  • Yang CL, Wang ZH, Subramanya AR, Ellison DH. Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive cotransport. J Clin Invest. 2005, May;115(5):1379-87. PMID: 15841204.

  • Al-Nimri MA, Komers R, Oyama TT, Subramanya AR, Lindsley JN, Anderson S. Endothelial-derived vasoactive mediators in polycystic kidney disease. Kidney Int. 2003, May;63(5):1776-84. PMID: 12675853.